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The inability to properly restore cellular homeostasis due to the negative effects of oxidative and ER stress can induce apoptosis in insulin-secreting beta-cells
It is important to state up front that different links in this chain rest on very different quality of evidence, and that a mechanistic story can be internally coherent at every step while still failing to describe what actually happens in a dosed animal or human
But they're slightly different in how they work, as well as in their potential benefits and side effects
Desole MS, Esposito G, Enrico P, Miele M, Fresu L, et al
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