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17 patients with eGFR 60 ml/min/1.73 m 2 received in a random order a single subcutaneous dose 1.2 mg liraglutide and placebo with subsequent 24 h blood pressure and natriuresis monitoring

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This is especially common in single-pathway drugs (GLP-1 only)

FIGURE 2 2.1.1 Calcium channel modulation Recent research has shown that exendin-4, a GLP-1RA, suppresses L-type voltage-gated calcium channels (L-VGCC) activity through a cascade involving cAMP/PKA, ryanodine receptors, and calmodulin (CaM)

As a 16-amino-acid peptide, it would likely be degraded by digestive enzymes if swallowed