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1 Findings Findings Among the 550 participants who received SGLT-2is at baseline, the primary outcome occurred in 14.4% of those in the semaglutide group compared to 13.9% of those in the placebo group (HR 1.07, 95% CI 0.69-1.67)
Regarding Diabetes mellitus management, the effect of metformin, a classic anti-diabetic drug, on epilepsy is controversial: on the one hand, studies have confirmed that it, as an AMPK agonist, activates thalamic AMP-activated protein kinase, thereby enhancing metabotropic GABAB receptor function and ultimately promoting absence epileptic seizures (95)
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