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The studies began with the determination of the optimal dosing for Cagrilintide in both chow-fed and high-fat diet (HFD)-fed wild-type (WT) mice, followed by analyses of its receptor dependence using receptor activity-modifying protein (RAMP) knockout (KO) models, and mechanistic studies involving neuronal activation and gene expression profiling [2]
Biochem Biophys Res Commun 1994, 204: 753-758
One explanation for the necessity to use double exponential fits for the second phase could be that a fraction of the roGFP2 WT (SH) 2 -PfGrx(SSG) intermediates glutathionylates the roGFP2 moiety of another molecule in trans
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