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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)
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SIPS can be caused by various factors including persistent exposure to cell stress, namely, oxidative stress or DNA-damaging mediators 28,29
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Nausea and rapid heart rate can occur
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