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Cryogenic electron microscopy data indicate that at least for the echovirus serotype 6m, polar interactions between the 2 domain of FcRn and proteins in the viral coat may enable a viral association with the receptor at the cell surface and trigger endocytosis and a pH-dependent destabilization of the viral particle
DN30 is involved in decreasing the c-Met signaling pathway through a variety of ways, including c-Met destruction, reducing c-Met expression, c-Met proteolytic detachment, and shedding c-Met from the cell surface, providing traps for HGF [162, 170]
The melanosome: membrane dynamics in black and white.Nature Reviews Molecular Cell Biology
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Specifically, peptidic agonist (NNC0712 for GCGR and peptide 5 for GLP-1R) binding reshapes the orthosteric pocket but cannot appropriately reorganize the central polar network to propagate extracellular signals 30,31
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