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Some compounded glutathione formulations exceed the solubility limit and form microcrystals that don't absorb

Importantly, these medications carry boxed warnings for medullary thyroid carcinoma risk and are contraindicated in patients with personal or family history of MEN2 or medullary thyroid carcinoma

This concern would always be there with questions of patient noncompliance, but this study design in particular lends itself to this type of error

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At the same time, caution is warranted in patients with current or previous eating disorders or psychiatric comorbidity, because GLP-1RAs may theoretically improve, maintain, or worsen eating-disorder symptoms depending on the individual context (108)