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These medications work by mimicking a hormone your body already produces (glucagon-like peptide-1) which slows digestion, curbs appetite, and helps regulate blood sugar
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According to a study of 81k women and 39k men, a higher intake of dietary phosphatidylcholine (source of TMAO) resulted in a higher all-cause death, especially among diabetics [9]
The relevant research observation is that human literature exists and is highly protocol-dependent
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