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224,225 A randomized controlled trial demonstrated that a high-dose B-complex vitamin reduced measures of oxidative stress and inflammation, and studies have shown that B vitamin supplementation is associated with reduced risk for stroke

5a), it is still a pharmacological avenue that might have off-target effects

Manganese peptide complexes (e.g., manganese tripeptide-1) have been explored as alternatives that avoid copper-related skin discoloration concerns while providing metal-dependent enzymatic activation

John Myers in the 1950s for patients who were not responding to oral supplements

10.1016/j.tcb.2015.10.014 Trends Cell Biol