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What happens after the weight comes off Stopping medication is often the most vulnerable part of the journey
This three-pathway mechanism is one reason retatrutide has gained significant attention in obesity medicine and clinical research, and why many are already referring to it as the next generation of weight-loss medications. Clinical trials for retatrutide began several years ago, with Phase 2 data generating significant interest due to the amount of weight loss observed in study participants
Success requires physician supervision, objective body composition monitoring (not just scale weight), and integration with proper nutrition and exercise foundations for optimal metabolic outcomes
How to Use Ozempic Ozempic is administered as an injection once a week
## Availability Status: March 2026 - **FDA status:** Phase 3 clinical trials ongoing - **Expected approval timeline:** Potentially 2026-2027 - **Brand availability:** None yet - **Current access:** Compounding pharmacies (503A/503B) with valid prescription For a detailed breakdown of [retatrutide's FDA approval status and projected timeline](/guides/retatrutide-fda-approval-2026-timeline-status), see our dedicated tracker the date brand pricing becomes available depends directly on when retatrutide clears FDA review
