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A 2025 narrative review of musculoskeletal research described both the regenerative findings and the open questions about translation to human clinical use (PMID 40789979)
Not having enough can cause serious nerve problems
In addition, decreased live fetal weight occurred in high dose rats, but not in rabbits
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The Phase 2 NEJM trial showed 24.2% average body weight reduction at 48 weeks in the 12mg group
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