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doi: 10.1016/j.annonc.2020.11.011

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Estradiol promotes anti-apoptotic pathways by enhancing the transcription of anti-apoptotic genes such as B-cell lymphoma 2 (BCL2) (202) and inactivating pro-apoptotic proteins such as BAD (BCL2 associated agonist of cell death) (203, 204)