Selectivity profiling against ACTH, cortisol, and prolactin readouts
But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established
Sources: Reinwald, C., Schauer, C., Csepregi, J., Kienhfer, D., Weidner, D., Malissen, M., Mocsai, A., Schett, G., Herrmann, M
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Genetic and epigenetic factors determining MASLD have been recently reviewed by Jonas and Schurmann (Jonas and Schurmann 2021), and the role of gut microbiota in mediating MASLD development was summarized by Campo et al