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BCAAs can promote cellular anabolism, fueling the citric acid cycle and promoting the biosynthesis of proteins and lipids, through mTOR activation, which correlates to tumor aggressiveness in a mouse model of hepatocellular carcinoma [157]

Lipid peroxide accumulation may be fatal to the cells as an integral event in ferroptosis (96)

Additional cardiovascular benefits may be provided by combination therapy with other antidiabetic medications, such as SGLT2 inhibitors

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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes