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4.1 Pharmacokinetic and pharmacodynamic considerations of antioxidant supplementation in AMS As mentioned above, oxidative stress has been proposed as a key contributor to the pathophysiology of AMS, driven by hypobaric hypoxiainduced mitochondrial dysfunction, increased ROS generation, endothelial activation, and neurovascular dysregulation
It stimulates the pituitary gland to produce and release growth hormone
Nature 455 (7210), 232236
Peters, E
HCs were additionally excluded if they have been diagnosed with a chronic pain condition or have a history of depression
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