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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

10.1056/NEJMoa050493 11 ButtgereitF.BurmesterG

L.FlynnJ

Recent studies have shown that MDSCs in gastric cancer upregulate TRAIL-Rs, making them susceptible to apoptosis when TRAIL-R signaling is activated [115]