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In the early stages of AD, mitochondria are unable to produce enough energy due to A peptides and phosphorylation of tau, and therefore impaired mitochondria eventually cause excessive production of ROS (70)
Furthermore, because our study was conducted in normal aging rats, without diabetes or other pathological conditions such as Alzheimers disease, we aimed to use the lowest effective dose to minimize potential adverse effects while still achieving beneficial effects on the brain
Gastroenterology 2007
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