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Research indicates that an untreated or poorly managed thyroid can cause the body to burn 100 to 400 fewer calories per day, leading to: Unexplained weight gain or difficulty losing weight
One significant limitation in the study of comorbid conditions is the lack of transcriptomic data from human patients and animal models of DM2-AD comorbidity in public repositories such as ArrayExpress 26 and Gene Expression Omnibus (GEO) 27
Women who are pregnant, breastfeeding, or planning to become pregnant should not use tirzepatide due to limited research on its safety in these situations
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