Both affect GLP-1 receptors, but tirzepatide also targets GIP receptors, creating a dual-action effect
But others, like the positive impacts we are seeing for individuals who have an alcohol addiction, may point to other impacts of these drugs
Nuciferine, a main bioactive component in the lotus leaf, when treated with HFD rats showed a significant decline in the ratio of Firmicutes/Bacteroidetes phyla which resulted in reduced blood endotoxemia and inflammation along with increased intestinal integrity and SCFA synthesis (Wang et al., 2020)
The optimal dosing window is days 46 of the injection cycle, when tirzepatide plasma concentration has declined from peak but therapeutic satiety and metabolic effects remain active
Ishida, J., Saitoh, M., Ebner, N., Springer, J., Anker, S