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Of note, although inhibition of PPAR diminished the glucose-lowering effect of GLP-1GIPLani, antagonization of PPAR did not ameliorate weight loss induced by either GLP-1GIPLani or the selective PPAR agonist GW501516 (Fig
To address these limitations and improve evidence-based guidelines for clinical practice, large-scale prospective studies and standardised real-world analyses are required in the future
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