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The community's 250 mcg twice weekly (0.5 mg/week, ~70 mcg/day equivalent) is conservative compared to clinical data (FDA implant ~14 mg/week), and the newer ~50 mcg/day loading dose is lower still

Exclusion criteria were syndromic obesity, pregnancy, severe disease (including all forms of diabetes mellitus), abnormal QT-interval and any treatments influencing blood glucose, weight, or other parameters of the metabolic syndrome

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