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Liraglutida, administrada a una dosis de 1,8mg diarios durante 48 semanas, demostr resolucin de la esteatohepatitis no alcohlica (sin empeoramiento de la fibrosis) en el 39% de los pacientes, en comparacin con el 9% con placebo, en un ensayo de fase 2 que incluy a 23 pacientes con obesidad (IMC 34,24,7kg/m2) y evidencia clnica de esta enfermedad
Maintenance treatments are recommended for lasting effects
J.HarnnoiT.UdomsinprasertR.JirajaroenratK.KettermanA
A novel peptide mimetic, FN075, was found to promote endogenous -syn aggregation in vivo , and injection of FN075 into the substantia nigra of rats resulted in motor dysfunction and loss of dopaminergic neurons, suggesting that -syn aggregation is associated with the development of PD (Olsen et al., 2019)
Dodd S et al (2019): Highly Variable Pharmacokinetics of Tyramine in Humans and Outcomes Associated with Treatment of Depression with Monoamine Oxidase Inhibitors
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