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In addition to the polyphenolic compounds structure, the pH or ion form (Fe 2+ and Fe 3+ ) influences both binding strength and total ion concentration

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Its application has been studied extensively in clinical settings, especially for those dealing with obesity or insulin resistance

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However, it can cause several gastrointestinal symptoms that are also seen in UC, such as: constipation or diarrhea abdominal pain constipation In fact, theres some evidence that it can improve symptoms of UC