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Glycemic control appears to be more effective when both receptors are activated [99, 100]

Basu A, Charkoudian N, Schrage W, Rizza RA, Basu R, Joyner MJ: Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride

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GIP stimulates a portion of the brain that creates a feeling of fullness, so patients dont get as hungry

Melanotan 2 is not FDA-approved for any indication and carries significant side effects.