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The swelling observed is primarily due to the recruitment of immune cells to the injured site, which increases vascular permeability, facilitating the extravasation of plasma proteins and fluids into the surrounding tissue
This reflects general industry standards under USP General Chapter 797
Concomitant medications like beta blockers blunt increases, while drugs that raise sympathetic tone can amplify them
When reconstituting, direct the bacteriostatic water along the inside wall of the vial rather than directly onto the powder
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