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Additionally, SGLT2i can lower HbA1c levels by 0.5-1.0% and support weight loss ( Studies have indicated that increased expression of the sodium-hydrogen exchanger isoform 1 (NHE-1) is linked to heart failure and may contribute to the development of hypertrophy and cardiac injury during ischemia and reperfusion ( Of note, long-term use of SGLT2i may lead to a reduction in glycosuric efficacy, without a corresponding decline in cardiovascular benefits
Acknowledgments We thank the Department of Science and Technology, New Delhi, India, for financial assistance in the form of the Inspire Research Fellowship (IF 150691)
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Patients with BMI 27 to 29.9 may qualify when conditions such as high blood pressure, prediabetes, diabetes, high cholesterol, or sleep apnea are documented
