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They were assigned 10 or 15 mg of tirzepatide or placebo for 52 weeks

As a complex process involving various transcriptional cascades, signaling pathways, and molecular mechanisms, significant effort has been made to identify the most suitable adipogenesis regulators to serve as potential therapeutic targets

The study found that about 10% of people carry genetic variants linked to a phenomenon known as GLP-1 resistance

doi: 10.1210/en.2011-0174, 76 KastinA

Although these results hint at potential beyond-weight reproductive benefits (83), the extremely small sample size ( n = 28), open-label design, and lack of objective measurements for key biological intermediates (e.g., oocyte/embryo quality and endometrial receptivity), combined with controversies over the adequacy of the washout period, mean these conclusions should be viewed as exploratory rather than definitive