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glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long-term (52-week) extension of a 52-week randomised controlled trial

If you want a deeper explanation of how this compares with other GLP-1 treatment options, our guide on how to get GLP-1 for weight loss is a useful next read

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When amino acids reach the small intestine, they directly trigger L cells to release GLP-1 through nutrient-sensing mechanisms involving the calcium-sensing receptor (CaSR) and peptide transporter 1 (PEPT1)

A structured medical weight loss program should begin with a physician evaluation and include ongoing physician oversight