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The proportion of new users without FDA-approved indications rose from 0.21% to 0.37% from 2019 to 2023

These preclinical observations in rodents promote continued study with the aim of translation to larger animals and specifically primates, the central focus being the quantification of therapeutic index when administered for sustained periods

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Collagen peptides operate through entirely different mechanisms than retatrutide and do not interact with GLP-1, GIP, or glucagon receptors