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Variability within the non-cognitive impairment group in baseline cognitive status, coupled with inconsistencies across studies in stimulation protocols, motor interventions, and cognitive assessment tools, collectively contributes to increased effect estimate variability
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T2DM is a metabolic disease caused by acquired endocrine disorders
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Insulin gene expression is upregulated in pancreatic -cells after GLP-1R activation, which increases insulin mRNA expression through activation of transcription factors such as pancreatic and duodenal homeobox-1 and cAMP-response element binding protein (Table 1), contributing to an increase in -cell numbers ( TABLE 1 Mechanism of glucose-lowering action of GLP-1R
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