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After the optimization of the human brain tissue processing methodologies, researchers not only provide evidence for the persistence of adult hippocampal neurogenesis both in physiological and pathological aging in humans but also reveal a progressively declined neurogenesis as AD advanced (Moreno-Jimenez et al., 2019)

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Glucose-dependent insulinotropic polypeptide receptor agonism may further augment insulinotropic and metabolic effects when combined with GLP-1 receptor activation