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J Neurochem 1996, 67, (3), 132831, Polis, B
Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage
Taspoglutide, an experimental diabetes drug built to closely mimic a hormone the body already produces, generated antibodies against itself in about half the patients who took it and systemic allergic reactions in 6%, including anaphylaxis, and Roche stopped dosing patients in the phase 3 trials in 2010
"Efficacy and Safety of a Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients with Type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial." The Lancet, 2021, 398(10295), 143-155
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