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In vitro characterization of procaspase-1-cleaving proteases We selected X(PC4)c, hereafter referred to as X(PC), from the final round of dual-selection PACE for detailed analysis due to its robust expression and ease of purification (see Fig
Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ
Among the cells that successfully escaped senescence, increased expression of the SLC1A5 variant of mitochondrial glutamine transporter and enhanced glutamine synthesis were noted, safeguarding these cells against glutamine deprivation [49]
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