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A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes
Tirzepatide-related nausea is usually temporary and manageable, but hydration and medical guidance are important if symptoms persist or include vomiting
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Our program draws from a comprehensive toolkit of evidence-based treatments used strategically in combination, not in isolation
Figure 15: PIONEER 1 closed testing procedure Source: Clinical Study Report
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