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Weeks 1-4: Foundation Phase The first four weeks establish whether you respond to AOD-9604 and whether the protocol suits your body
This dose is set to keep Vitamin B12 levels in the body after the initial doses fix the deficiency
Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
