3 Emerging research suggests GLP-1 medications may be particularly effective for menopause weight gain: A 2025 study presented at the Menopause Society meeting found that postmenopausal women on hormone replacement therapy (HRT) lost 19.9 percent of their body weight on tirzepatidesignificantly more than the 15.6 percent loss seen in postmenopausal women not using HT
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Upper/Lower Gastrointestinal Symptoms Adverse event reporting databases, RCTs, and real-world data consistently show that GLP-1 RAs are commonly associated with GI symptoms such as nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspeptic complaints
M., D'andrea, P., and Pompili, S