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Semaglutide has become one of the most consequential molecular franchises in pharma in recent memory
Small but statistically significant increases in lactate levels (up to 2-fold) were observed in a few animals at approximately the clinical exposure
While these symptoms have many potential causes, they require evaluation to rule out thyroid pathology, given the FDA's boxed warning regarding thyroid C-cell tumors
Bhashyam S, Fields AV, Patterson B, Testani JM, Chen L, Shen Y-t, Shannon RP: Glucagon-like peptide-1 increases myocardial glucose uptake via p38 MAP kinasemediated, nitric oxidedependent mechanisms in conscious dogs with dilated cardiomyopathy/clinical perspective
This may make it more effective in supporting long-term weight loss and metabolic health
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