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However, the agency also warns that trying to lose weight with an unapproved GLP-1 drug can be risky for patients. Others have raised concerns regarding the safety of compounded weight-loss drugs, which can cost hundreds of dollars less than FDA-approved treatments
Phase 3 data showed weight loss of 7.5% to 11.2% at 72 weeks depending on dose, with head-to-head data showing orforglipron 36 mg producing 73.6% greater weight loss than oral semaglutide 14 mg
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To do this, it may send a little less blood to your hands and feet to conserve heat, which can make them feel colder than usual
Never reuse needles, as they become dull after a single injection and cause tissue trauma, increased pain, and risk of infection
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