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Treatment of Otsuka Long Evans Tokushima Fatty (OLETF) rats, an obese animal model of type 2 diabetes, with the PPAR agonist fenofibrate reduced the decline in beta cell mass and prevented the development of diabetes [23]
En conjunto, incluso la combinacin de estos efectos modestos sobre los factores de riesgo cardiovasculares clsicos puede no explicar por completo los resultados beneficiosos observados en los CVOT de GLP-1 RA
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