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Patients in trials typically begin to notice appetite suppression and early weight loss within the first few weeks of treatment

Arese M, Strasly M, Ruva C, Costamagna C, Ghigo D, MacAllister R, Verzetti G, Tetta C, Bosia A, Bussolino F (1995) Regulation of nitric oxide synthesis in uraemia

Actually, let me reframe that

Head-to-head trial result SURMOUNT-5 found tirzepatide produced about 20% average body weight loss versus roughly 14% for semaglutide over 72 weeks in adults with obesity

Increasing HbA1c level was found to be negatively associated with plasma GLP-1 responses ( We also measured total GLP-1 and not the active, intact GLP-1 (736 amide) levels