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Understanding the distinct evidence base, regulatory status, and safety profile of each agent and the complete absence of clinical data on their combined use is essential for patients and healthcare professionals navigating this rapidly evolving and largely unregulated landscape

If you are taking insulin or sulfonylureas, doses may need careful adjustment to avoid hypoglycaemia when changing therapies

Every effort was made to minimize the number of mice used in the experiments and their suffering

However, metoclopramide should only be used for up to 5 days, and domperidone has restrictions due to cardiac risks, so any anti-emetic should only be used under medical supervision

Improper use can lead to complications such as scarring, infections, or severe nerve injury , especially when unapproved, off-brand, or self-administered products are used