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Adipokine dysregulation, inflammation, and alterations in gut microbiota have been identified as significant pathophysiological contributors, according to evolving research [34]

In laboratory settings, it has been examined for its interaction with GLP-1 pathways and its role in neuroendocrine and metabolic signaling

Importantly, a randomized controlled trial demonstrated that L-carnitine supplementation reduces the intramyocellular-to-extramyocellular lipid ratio in NAFLD patients, suggesting enhanced clearance and utilization of intracellular lipid stores in skeletal muscle independent of weight changes (41)

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Candido R, Gaiotti S, Giudici F, et al