semaglutide sglt2 inhibitor once weekly as add-on to SGLT-2 therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial semaglutide sglt2 inhibitor Inhibitors and

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Combination with Metformin or Metformin with SGLT-2 Inhibitors In a 26-week, double-blind, double-dummy trial (Trial 4, NCT02863419), 711 adult patients with type 2 diabetes mellitus on metformin alone or metformin with SGLT-2 inhibitors were randomized to RYBELSUS 14 mg once daily, liraglutide 1.8 mg subcutaneous injection once daily or placebo

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Smaller aggregates (called sub-visible particles) are too small to see but still problematic