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In a public advisory on Wednesday, Health Canada said that as interest grows in GLP-1 products for weight loss, "some people may turn to unauthorized or counterfeit products, which could pose serious health risks because they have not been assessed by Health Canada for safety, effectiveness, or quality." The versions of the medications authorized for use in Canada are semaglutide (Ozempic and Wegovy injections and Rybelsus oral tablets) and tirzepatide (Mounjaro and Zepbound injections)

(2,4) In 1990, a ground-breaking study reported that in men aged 61 to 81, six months of intravenous GH therapy reversed physiological changes incurred during 10 to 20 years of aging

In drug repositioning it is crucial to understand the disease-drug relationship, for this reason, there are several approaches to address the problem: In silico approaches: in this type of approach, various public databases, clinical trials, and bioinformatic systems are used to identify drug-target interactions ( Cluster approaches tend to find new drug-target or drug-disease relationships (Parisi et al., 2020)

Clinical Nutrition ESPEN , 41 , 439-442

doi: 10.1056/NEJMoa1811744 53 PfefferM