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A study has shown that lixisenatide inhibits inflammation of RA in human FLSs by downregulating IL-6, IL-8 and TNF-, while also inhibiting cellular communication pathways including c-Jun N-terminal kinase (JNK) and NF-B [239]
For initial trials, a lower dose of 100-250 mcg is recommended, with adjustments made based on the subjects response and study objectives
Regardless, weight loss varies depending on dosage, diet, physical activity, and levels
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