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Side effects mostly include nausea, heartburn, and abdominal discomfort associated with decreased gastric motility, which can be prohibitive for some patients
Cobalamin separates from the protein during digestion, and a substance called intrinsic factor binds to cobalamin for the body to absorb it into the blood
Manage gastrointestinal side effects proactively
The SURMOUNT-1 clinical trial analyzing the efficacy of tirzepatide for weight loss showed that 4.8% of people taking the 5 mg dose discontinued the treatment, followed by 6.3% taking the 10 mg dose, and 6.7% taking the 15 mg dose
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