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Ronn et al
My team and I set out to test whether GLP-1 drugs medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound), originally developed for diabetes and then approved for obesity could do what no existing addiction treatment does: curb craving itself
These data reveal that distinctions in peptide N-terminal interactions and dynamics with the GLP-1R transmembrane domain are reciprocally associated with differences in the allosteric coupling to G proteins
That same 0.25mg dose from a 2.5mg/ml solution requires 10 units
Switching to Wegovy with a BMI under 27 is generally not recommended because the medication is specifically approved for higher BMI ranges or weight-related health conditions
