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doi:10.1016/j.molmet.2018.09.009
The changes in the levels of various lipid species that result from the imbalance between lipolysis/lipid uptake/lipogenesis and lipid oxidation/secretion can cause organellar dysfunction, e.g
The most common side effects were mild to moderate gastrointestinal issues, with about one-third of patients on the highest orforglipron dose experiencing nausea and about one-quarter experiencing constipation or diarrhea
These products are also largely unregulated
Retatrutide carries the side-effect profile of the GLP-1/GIP class nausea, vomiting, diarrhoea, constipation plus the class-level concerns we know from Mounjaro and Wegovy: gallbladder disease, pancreatitis, kidney injury from severe dehydration, and a possible thyroid C-cell tumour signal seen in rodent studies
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