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During traditional dieting, the body responds to caloric deficit by increasing ghrelin (the hunger hormone), decreasing leptin (the satiety hormone), reducing thyroid hormone output, and increasing cortisol

Gut-health peptides might reduce gastrointestinal side effects (nausea, gut motility changes) by stabilizing mucosal function

Available at: Last update: 6/2014

The international or national clinical trial registries, including the ClinicalTrials.gov, European Union Clinical Trials Register, World Health Organization-International Clinical Trials Registry Platform and 9 national clinical trial registries were also searched

Appetite suppression persists but caloric deficit narrows