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For a common working concentration of 2.5 mg/mL, add 2 mL of solvent directly to the lyophilized vial and allow it to dissolve gently without vortexing, as aggressive agitation can cause peptide aggregation and loss of bioactivity
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9-11 It should be noted that there are several well-designed landmark trials investigating a GLP-1 RA in addition to basal insulin with placebo or other comparators
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